Not all collagen is created equal. The type, source, molecular size, composition, and manufacturing processes can differ greatly between collagen products. Radiance uses a special matrix of collagen that has undergone almost two decades of development, complete with clinical trials.
The Collagen That Finally Does It All
The Benefits You Care About
Healthy, lustrous hair
Joint comfort & mobility
Strong, beautiful nails
Reduce facial lines, wrinkles and crow’s feet
Skin elasticity and moisture
BioCell Collagen Clinical Studies
HUMAN CLINICAL STUDIES – JOINT HEALTH
HUMAN SKIN STUDIES – BEAUTY-FROM-WITHIN
1. Effect of BioCell Collagen®, on Improving Joint Comfort: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Eighty subjects were divided into two groups and administered either 2 g of BioCell Collagen® supplement or placebo for ten weeks.
- Compared to placebo, the BioCell group had a significant improvement of joint comfort on days 35 (p = 0.017) and 70 (p < 0.001).
- BioCell group experienced a significant improvement in physical activities compared to the placebo group on days 35 (p = 0.007) and 70 (p < 0.001).
- BioCell Collagen was well tolerated and found to be effective, thereby improving mobility and quality of life.
The peer-reviewed study was published in the Journal of Agriculture and Food Chemistry. (https://pubs.acs.org/doi/10.1021/jf205295u) (Schauss et al., 2012).
Results of study – Min. 30% improvement in 71% of subjects taking BioCell Collagen
2. A Randomized Double-Blind Clinical Pilot Trial Evaluating the Safety and Efficacy of BioCell Collagen® in Adults for Joint Comfort
- Sixteen subjects split evenly into two groups, ingested 1000 mg of BioCell Collagen® twice daily (2 g) or placebo for eight weeks.
- As compared to the placebo group, the BioCell group showed 40% improvement
- No adverse events associated with BioCell Collagen.
The study details were presented at the international conference of Experimental Biology, 2004, Washington, DC.
Results of the study – 40% improvement
3. BioCell Supplement on Subjective Discomfort (1999)
- This 89 subject, prospective, crossover double-blind clinical study compared 2 g daily supplementation of the BioCell ingredient versus placebo over three months.
- Out of the 89 participants who complained of subjective discomfort of various types, 80 of them (89%) reported some level of improvement within 45 days of taking the BioCell supplement.
- In contrast, only one subject on placebo had improved.
- No adverse events with the BioCell supplement. (1999 unpublished study)
Results of study – Effective in 89% of subjects
4. Effects of BioCell Collagen® on connective tissue protection and functional recovery from exercise in healthy adults.
- In this pilot study, 3 g of BioCell Collagen supplement daily for six weeks enhanced recovery following weight training exercise and favorably impacted certain bio-markers of tendon and ligament connective tissue.
The study findings were published in the Journal of the International Society of Sports Nutrition (JISSN): http://www.jissn.com/content/11/S1/P48
1. Ingestion of BioCell Collagen®; enhanced blood microcirculation and reduced facial aging signs.
- Twenty-six healthy female subjects aged 35 to 59 years of various ethnic origin.
- Subjects ingested 1 g of BioCell Collagen® daily in two equally divided doses, morning and evening for 12 weeks.
- BioCell Collagen® demonstrated the following results:
- Significant reduction of facial lines and wrinkles
- Significant reduction of facial skin dryness and scaling
- Significant increase in facial dermal collagen content and microcirculation
- The study findings are published in the journal of Clinical Interventions in Aging (2012).
2. BioCell Collagen® Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial..
- One hundred thirteen healthy female subjects aged 39 to 59 years.
- Subjects ingested 1 g of BioCell Collagen® daily in two equally divided doses, morning and evening for 12 weeks.
- BioCell Collagen® demonstrated the following results compared to a placebo:
- Significantly reduced facial lines and wrinkles (P = .019) and crow's feet lines and wrinkles (P = .05)
- Significantly increased skin elasticity (P = .008) and cutaneous collagen content (P
- Significantly improved indicators associated with a more youthful skin appearance based on visual grading and wrinkle width (P = .046)
- Decreased skin dryness and erythema
- The study findings are published in the journal of Alternative Therapies in Health and Medicine (2019).
Why Radiance is Better
Collagen Supplementation: An Overview
Collagen comes in many forms (at least 28!), and it is incorporated into nearly all of our body’s tissues. In fact, over 30% of all the body’s proteins are in the form of collagen. Unbeknownst to most people, collagen is the most abundant protein in the body. Where we really come to care about collagen is in our skin, hair, bones, cartilage, and joints. However, as we age, our bodies produce less and less collagen, leading to undesirable wrinkles, dry skin, aching joints, and brittle bones.
Differences in Skin with Sufficient or Insufficient Collagen.
Collagen, like other proteins, is made up of amino acids, which are the building blocks of skin, tendons, muscles, and most other essential bodily structures. A key feature of collagen’s amino acid composition is a high concentration of the anti-aging amino acid, glycine, which has recently demonstrated robust effects in the prevention of aging (1). What is truly unique about collagen is its triple helical structure, just like a braid of hair or a steel cable; it is strong but elastic, firm yet pliable. As you can see, these are the properties that make collagen so vital for maintaining healthy joints and youthful skin.
Taking a collagen supplement has been shown to effectively combat declining collagen levels, as well as maintain and improve already healthy skin and joints. Much of the damage incurred on skin comes from radiation exposure, in other words, sunlight. Pyun et al. (2) found collagen supplementation to greatly improve skin hydration, elasticity, and color after exposure to sunlight. Kim and colleagues (3) concluded that collagen supplementation “is not only an anti-wrinkling agent but also a potent candidate as a [skin] moisturizer.” Collagen has also demonstrated significant improvements in joint discomfort in both those who are young and active (4) as well as the general population (5). Finally, collagen supplementation has been shown to inhibit the deterioration of bone health in aging individuals (6). If we haven’t shown you enough, let’s take a few extra steps.
Collagen: The Science
As stated, collagen is a triple helix structure. It consists of 3 polypeptide chains, or “many amino-acid” chains, all wrapped around one another. Every third amino acid is glycine, while the other two spaces are most often filled by prolines or lysines. Glycine, due to its small size, provides a degree of flexibility and elasticity, while proline and/or lysine, the larger amino acids, deliver rigidity and strength. Each triple helix collagen structure aligns itself next to another, conjoined by a proteoglycan (a protein bound to carbohydrate molecules), until a small fibril is formed. This fibril may stand alone, or, in the case of thicker tissues such as tendons or ligaments, many more collagen fibrils intertwine to form a fiber, similar to that of a steel cable in design.
The amino acid sequence and form of collagen.
In the amino acid sequence, GLY indicates a glycine, while PRO and HYP indicate other amino acids, in this case, proline and hydroxyproline (a proline with an extra oxygen and hydrogen atom).
Another important player to consider when it comes to bodily tissues is hyaluronic acid. Hyaluronic acid has a less complex structure than collagen – it is a straight line of glucosamine and galactosamine, two sugar-amino acid compounds. Hyaluronic acid is very concentrated in “wet” areas of the body, such as the skin, synovial fluid (joint lubricant), cartilage, and bone (the bone marrow houses and makes all the important immune cells that make up our blood system, so it is in fact very “wet!”). Its pivotal role in these wet areas of the body makes hyaluronic acid a very important component for improving joint, skin, and bone health.
Collagen and hyaluronic acid are intimately related and overlap in their function; hyaluronic acid is actually “stored” within collagen. Each fiber (such as a tendon) in our body is made up of thousands of collagen chains, which are held together by proteoglycans. This structure is made up of hyaluronic acids. Therefore, hyaluronic acid and collagen are the building blocks that build the tissues and sinews that hold our body together.
Collagen Fibrils Conjoining with the Help of a Proteoglycan.
For an example of the intimate relationship between collagen and hyaluronic acid in our body, let us consider the knee. There is collagen surrounding the end of the femur (thigh bone) and tibia (shin bone) in the form of an articular cartilage. Articular cartilage is the type of cartilage that comes into contact with another cartilage in a joint. Hyaluronic acid keeps the cartilage malleable, so that it serves to protect the joint from damage due to friction between the weight-bearing bones. It is also present in the synovial fluid, which reduces the friction by providing lubrication within the joint space. Collagen is also found in the ligaments (connecting bone to bone) and tendons (anchoring muscle to bone) surrounding the knee, as well as in the joint capsule (connective tissue surrounding the entire knee joint), which keeps synovial fluid inside the joint. Of course, collagen is also present in the femur and tibia themselves, providing over 90% of the bones total protein (7).
The Differences Between a Healthy Knee and an Arthritic Knee. The cartilage (in blue) is rich in collagen and protects the bones.
In the skin, the biggest organ system in our body, the collagen and hyaluronic acid keep everything firm and smooth. Luckily, much like the other tissues discussed already, our skin is mostly composed of collagen. Lines, wrinkles, and even cellulite occur when the collagen lattice structure in the skin is either damaged or weakened. Collagen works from the inside out; it is created in the fibroblasts of the deep skin and rises to the surface as skin cells die and are washed away. As the collagen rises, the valleys of the lines and wrinkles of the skin are raised to the surface by the new, firm collagen.
Progression of Skin with Low Collagen to Skin with High Collagen. Low collagen content of the skin (left) leaves fine lines and wrinkles, but as collagen proteins rise, they return the lines to their natural position, smoothing the skin.
Many of the general population have a basic understanding of the importance of collagen in our skin, joint, hair and bone health. And some may have even heard of the benefits of hyaluronic acid on skin. However, many probably did not know just how intertwined the two components are in making up the building blocks of our bodily tissues. Together with hyaluronic acid, collagen lubricates the joints to prevent damage due to friction and stabilizes the joint by connecting bones to muscles and other bones. Therefore, collagen supplementation, along with hyaluronic acid synergy, ensures that the body has the sufficient building blocks to form all the components that make up a healthy joint. Without adequate collagen, the joints erode and become stiff and painful. When the skin is left with low amounts of collagen, such as in old age when the fibroblasts produce much less collagen, the skin surface loses its turgor and elasticity, leading to the unsightly wrinkles. The loss of collagen can lead to areas of skin weakness that allow the subcutaneous fat to push and stretch the skin, forming the cottage cheese appearance of what we call “cellulite.” Therefore, collagen and hyaluronic acid supplementation supplies the body with the elasticity, moisture and strength needed for healthy joints and skin.
Radiance and Why it is the complete Collagen Formula
Most collagen formulas are basic in nature. They utilize a beef hide that sources merely collagen I and Collagen III in its’ matrix. As we have read above, there are 28 different types of collagen in the body. Most are made by the body but studies have shown that oral intake of collagen has improved skin, nails, hair, and joints. However, limiting one to just a complex of Collagen I and Collagen III limits our bodies capabilities.
Radiance contains a matrix of collagen peptides of Collagen I, II, III, V, and X. We also utilize a heavily studied ingredient in Biocell Collagen to give you not only the benefits of our collagen blend but also the science. This beloved collagen is a blend of type II collagen, chondroitin sulfate, and hyaluronic acid. Thus far, we have discussed the benefits of collagen but chondroitin sulfate and hyaluronic acid are critical in assisting collagen build joints, cartilage, and cartilage fluidity. So let’s give you a quick rundown of what we have in our product and why having a complex blend of collagen is key to your body's success.
Collagen 1 – Most common type of collagen
Prominent in hair, skin, nails, organs, bones, ligaments.
Supports healthy skin, hair, nails
Best Sources - Beef
Collagen 2 – helps build cartilage, joints, and maintains our gut lining
Supports joint and digestive health
Assists with immune health and function
Best Sources – Chicken
Collagen 3 – Commonly found alongside collagen 1
Supports organs, blood vessels, muscle structure
Best Sources – Beef, Fish
Collagen V – Less abundant but still important
Forms cell membranes, found in eyes, specifically in the cornea
Placenta of expecting mother
Best Sources – Eggs, Multi-Collagen Powders
Collagen X – helps form bones and joints
Best Sources – Eggs(eggshells), Chicken
Hyaluronic Acid – natural substance found in the fluids in the eyes and joint. Acts mostly as a lubricant. This ingredient in combination with collagen can help assist with joint and cartilage fluidity.
Chondroitin Sulfate – a major ingredient in the building of cartilage. A baseline supplement for many that have osteoarthritis. A major component in joints, and human skin.
A Recent systematic review and meta-analysis by Miranda et al, 8 took a look at 19 studies with a total of 1,125 participants aged between 20 and 70 years old. This group consisted of 95% women. This meta-analysis showed favorable results of hydrolyzed collagen supplementation vs placebo. What were the benefits you might ask? They were all the things we discussed above about the benefits of Radiance. The studies showed that the group taking the collagen supplementation had improved skin hydration, elasticity, and wrinkles. The results were amazing, showing that collagen can delay and improve the signs of skin aging by decreasing facial wrinkles and improving skin hydration. Our formulation with Biocell Collagen only highlights the intricate details we have put into our formula that is backed by customer reviews and backed by science. Another added benefit from this meta-analysis showed that there were no adverse effects reported with all 1,125 participants.
Give Radiance a try, knowing that it is backed by scientific evidence, GRAS (generally recognized as Safe) ingredients by the FDA, and formulated with your best skin, hair, and joints in mind.
- Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Iashikawa, K., Nakada, K., ... & Okita, K. (2015). Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. Scientific reports, 5.
- Pyun, H. B., Kim, M., Park, J., Sakai, Y., Numata, N., Shin, J. Y., ... & Hwang, J. K. (2012). Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Preventive nutrition and food science, 17(4), 245.
- Kim, J. K., Lee, J. H., Bae, I. H., Seo, D. B., & Lee, S. J. (2011). Beneficial effect of a collagen peptide supplement on the epidermal skin barrier. Korean Journal of Food Science and Technology, 43(4), 458-463.
- Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., ... & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current medical research and opinion, 24(5), 1485-1496.
- Schauss, A. G., Stenehjem, J., Park, J., Endres, J. R., & Clewell, A. (2012). Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: A randomized, double-blind, placebo-controlled trial. Journal of agricultural and food chemistry, 60(16), 4096-4101.
- Moskowitz, R. W. (2000, October). Role of collagen hydrolysate in bone and joint disease. In Seminars in arthritis and rheumatism (Vol. 30, No. 2, pp. 87-99). WB Saunders.
- Rodwell, V., Bender, D., Botham, K., Kennelly, P., and Weil, P. (2015). Harper’s Illustrated Biochemistry. New York: McGraw Hill [distributor].
- Roseane B. de Miranda1,2, MD, Patrıcia Weimer3, MD and Rochele C. Rossi2 , PhD Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. International Journal of Dermatology, 2021-12, Vol. 60 (12), p 1449-1461.
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