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ATP and Muscular Fatigue

When an athlete becomes fatigued, performance suffers. Everyone knows this is true, but why does it happen?

Muscular fatigue is caused by a decrease in muscular excitability, or the muscle’s ability to respond rapidly to a stimulating agent telling the muscle to contract. That stimulating agent is calcium.

Unfortunately, exercise depletes calcium from muscle cells, causing a decrease in muscular excitability and an increase in fatigue. In fact, a 50% decrease in calcium can result in an 80% reduction in force.1

The key to fighting muscular fatigue is to increase muscular excitability.
Increases in muscular excitability lead to an increase in the intensity of muscle contractions

FOUNDATION Creatine + Real ATP increases:
  • Muscle excitability*
  • Levels of extracellular calcium*
  • Blood flow*
  • Nutrient and oxygen delivery*
  • Waste removal*
FOUNDATION Creatine + Real ATP decreases:
  • Muscle fatigue*
  • Recovery time*
1Zhang SJ et al. Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle. J Psysiol. 2006;572(2):551-9.